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mavacamten will lower the extent or result of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Progestin and ethinyl estradiol are CYP3A4 substrates. Mavacamten may minimize systemic exposures of ethinyl estradiol and progestin, which may produce contraceptive failure or an increase